Pharmacology for Dopamine and Neurotrnsmitter- myassignmenthelp

Question: Discuss about thePharmacology for Dopamine and Neurotrnsmitter. Answer: Abstract Parkinsons disease is a long-term degenerative disorder in which the main effect is on the central nervous system of the body. The present video is on Parkinsons disease which mainly focuses on the pharmacological principles of managing the condition. A discussion is also put up regarding the pathophysiology of the disorder, relevance to practice and other considerations. The central nervous system is responsible for maintaining the chemical environment within the body for normal living processes. Parkinsons disease is marked by death of cells in the brain and the presence of Lewy bodies which are accumulations of protein alpha-synuclein. The basal ganglia exert a constant inhibitory influence on motor system with the help of dopamine, a neurotrnsmitter, controlling their activation. In case of Parkinsons disease, there are low levels of dopamine, leading to production of hypokinesia and reduction in motor output. Pharmacological treatment of Parkinsons disease focuses on the restoration of required level of dopamine in the brain. The drugs that are commonly administered for treating the symptoms of the disease are L-DOPA, dopamine agonists, Monoamine Oxidase B inhibitors, Amantadine, Anticholinergics and Catechol O-Methyl Transferase Inhibitors. L-DOPA is the main class of drugs used which is commonly known as Levodopa. It is a metabolic precursor of the catecholamine neurotransmitter dopamine. It is responsible for replenishing the depleted striatal dopamine. The pharmacokinetics is highly satisfactory. The drug is mainly administered orally. However, there are a number of side effects presented by the patient such as drowsiness, insomnia, agitation, nausea, vomiting, dizziness, and tachychardia. Precautions are to be taken while administering the medication. Patients suffering from this debilitating condition are to be provided with customized nursing care so that individualized needs of the patients are met. There immense potential for new research on Parkinsons disease in the future especially related to pharmacological management.